Oxlow Bridge School, covering 3,700 sqm of floor space, is to be built by Willmott Dixon on the site of a former council transport depot in Dagenham.
It will have space for 100 pupils with profound multiple learning difficulties from four to 19 years old.
Barking & Dagenham Council took just seven months to turn around the planning application from its regeneration arm, Be First.
Special facilities will include ceiling-mounted tracked hoists to provide connection between classrooms and adjacent hygiene rooms, a hydrotherapy pool and sensory & therapy rooms, which will all have ceiling-mounted tracked hoist.
The school is expected to open in 2025 and be carbon net zero in operation.
Willmott Dixon managing director Stewart Brundell said: “We are delighted that planning permission has been granted for The Oxlow Bridge School. This is testament to the hard work and collaboration of everyone involved in the project so far.”